PECULIARITIES OF TLR-2 (ARG753GLN) AND TLR-4 (ASP299GLY) POLYMORPHISM PREVALENCE IN PATIENTS WITH ACUTE BRUCELLEIS AND CARDIOVASCULAR SYSTEM DISEASES
نویسندگان
چکیده
منابع مشابه
quantitative evaluation of baff, hmgb1, tlr 4 and tlr 7 expression in patients with relapsing remitting multiple sclerosis
multiple sclerosis is a chronic inflammatory disease of the central nervous system characterized by a complex immune response. because of the complex nature of ms pathogenesis, a panel of biomarkers derived from different platforms will be required to reflect disease-related alterations. monitoring and evaluation of molecules associated with the pathogenesis of the disease would provide useful ...
متن کاملTLR-2 and TLR-4 expression in monocytes of newborns with late-onset sepsis.
OBJECTIVE To analyze toll-like receptor (TLR)-2 and TLR-4 expression in monocytes of newborns with late-onset sepsis. METHODS This prospective study included 27 full-term newborns aged 8 to 29 days, with clinical and laboratory diagnosis of late-onset sepsis. Ten newborns (37%) had positive cultures. Cytokines were measured by cytometric bead array in peripheral blood, while TLR-2, TLR-4 expr...
متن کاملHeterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease.
Lyme disease (LD) is caused by Borrelia burgdorferi and displays different stages, including localized, early disseminated, and persistent infection, all of which are associated with profound inflammatory reactions in the host. Induction of proinflammatory cytokines by B. burgdorferi is mainly mediated by outer surface proteins interacting with TLR-2/TLR-1 heterodimers. In this study, we show t...
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مقدمه: در عفونتهای پریودنتال پیش نیاز شروع پاسخهای میزبان، شناخت پاتوژنها توسط سیستم ایمنی میزبان میباشد. خانواده رسپتورهای Toll-like (TLRs)، مسئول شناسایی ساختارهای حفظ شده میکروبیال نظیر لیپوپلی ساکارید (LPS) باکتریها میباشند و مسیرهای سیگنال دهنده را که در نهایت منجر به پاسخهای ایمنی میشود، فعال میکنند. هدف از مطالعة حاضر، ارزیابی مقایسه میزان بروز TLR-2 و TLR-4 توسط تکنیک Real-...
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ژورنال
عنوان ژورنال: EUREKA: Health Sciences
سال: 2019
ISSN: 2504-5679,2504-5660
DOI: 10.21303/2504-5679.2019.00923